60018
Fluka
Caffeic acid
puriss. p.a., matrix substance for MALDI-MS, ≥99.0% (HPLC)
| Synonym: | 3,4-Dihydroxycinnamic acid |
| CAS Number: | 331-39-5 |
| Linear Formula: | (HO)2C6H3CH=CHCO2H |
| Molecular Weight: | 180.16 |
| Beilstein Registry Number: | 1954563 |
| EC Number: | 206-361-2 |
| MDL number: | MFCD00004392 |
| PubChem Substance ID: | 24881776 |
Description
| Biochem/physiol Actions | A natural dietary phenolic compound found in plants that is an anti-oxidant. Inhibits the synthesis of leukotrienes that are involved in immunoregulation, inflammation and allergy. Inhibits Cu2+-induced LDL oxidation. |
Properties
| grade | matrix substance for MALDI-MS |
| puriss. p.a. | |
| assay | ≥99.0% (HPLC) |
| form | powder |
| color | slightly beige |
| mp | 211-213 °C (dec.)(lit.) |
| cation traces | Ba: ≤5 mg/kg |
| Ca: ≤10 mg/kg | |
| Cd: ≤5 mg/kg | |
| Co: ≤5 mg/kg | |
| Cr: ≤5 mg/kg | |
| Cu: ≤5 mg/kg | |
| Fe: ≤20 mg/kg | |
| K: ≤50 mg/kg | |
| Mg: ≤5 mg/kg | |
| Mn: ≤5 mg/kg | |
| Na: ≤50 mg/kg | |
| Ni: ≤5 mg/kg | |
| Pb: ≤5 mg/kg | |
| Zn: ≤5 mg/kg | |
| suitability | in accordance for UV test |
| Gene Information | human ... ELA2(1991) |
| rat ... Alox5(25290) |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, Respirators |
| Hazard Codes | Xn |
| Risk Statements | 36/37/38-40-63-68 |
| Safety Statements | 26-36/37/39 |
| WGK Germany | 3 |
| RTECS | GD8950000 |
References
| Reference | Koshihara, Y., et al., Selective inhibition of 5-lipoxygenase by natural compounds isolated from Chinese plants Artemisia rubripes Nakai. FEBS Lett. 158, 41-44, (1983) |
| Koshihara, Y., et al., Caffeic acid is a selective inhibitor for leukotriene biosynthesis. Biochim. Biophys. Acta 792, 92-97, (1984) | |
| Yamanaka N. FEBS Lett. 405, 186-190, (1997) | |
| Ploemen, J.H., et al., In vitro and in vivo reversible and irreversible inhibition of rat glutathione S-transferase isoenzymes by caffeic acid and its 2-S-glutathionyl conjugate. Food Chem. Toxicol. 31, 475-482, (1993) | |
| Chan, W.S., et al., Structure-activity relationship of caffeic acid analogues on xanthine oxidase inhibition. Anticancer Res. 15, 703-707, (1995) | |
| Merck | Merck 13,1635 |
| Beilstein | Beil. 10,IV,1776 |
| reference | FT-IR 2 (2), 2643:B / FT-IR 1 (2), 184:D / FT-NMR 1 (2), 1058:B / IR-Spectra (2), 836:F / IR-Spectra (3), 955:E / NMR-Reference 2 (2), 181:C / RegBook 1 (2), 1779:D / Sigma FT-IR 1 (2), 358:A / Structure Index 1, 284:D:2 |
